Making use of single-molecule optical and AFM imaging and pressure-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests involve:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Within the similar time, the group of Paul McEuen, who was then based for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of person DNA molecules recaptured around 1000 occasions inside a strong state nanopore
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Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
You are a Christian. If you could possibly make this type of artificial cell, would you be one action closer to God, or would the position of God have diminished relatively all over again?
Movement-driven rotary motors for example windmills and h2o wheels travel purposeful processes in human society. Even though examples of these kinds of rotary motors also element prominently in mobile biology, their artificial design at the nanoscale has remained difficult. Right here we show circulation-driven rotary motion of a self-arranged DNA nanostructure that is definitely docked on to a nanopore in a skinny stable-condition membrane. An elastic DNA bundle self-assembles right into a chiral conformation upon phoretic docking onto the sound-state nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−one.
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It absolutely was throughout this period that Dekker performed research on magnetic spin devices and on sounds in superconductors and semiconductors.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, very first measurement of your wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for a new Luttinger description of interacting electrons in nanotubes
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart ceesdekker structure in 2005. (nl)